An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy

An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy

Impaired cargo trafficking and the aggregation of intracellular macromolecules are key features of neurodegeneration, and a hallmark of aged as well as diseased retinal pigment epithelial (RPE) cells in the eye. Here, photoreceptor outer segments (POS), which are internalized daily by RPE cells, wer...

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Bibliographic Details
Main Authors: Eloise Keeling, Annabelle J. Culling, David A. Johnston, David S. Chatelet, Anton Page, David A. Tumbarello, Andrew J. Lotery, J. Arjuna Ratnayaka
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
RPE
oxidized POS
proteolysis
lysosomes
autophagy
autofluorescence
Online Access:https://www.mdpi.com/1422-0067/21/18/6647

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https://www.mdpi.com/1422-0067/21/18/6647

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