Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling

Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling

Fetal endoscopic tracheal occlusion (FETO) is an emerging surgical therapy for congenital diaphragmatic hernia (CDH). Ovine and rabbit data suggested altered lung epithelial cell populations after tracheal occlusion (TO) with transcriptomic signatures implicating basal cells. To test this hypothesis...

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Bibliographic Details
Main Authors: Vincent Serapiglia, Chad A. Stephens, Rashika Joshi, Emrah Aydin, Marc Oria, Mario Marotta, Jose L. Peiro, Brian M. Varisco
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pediatrics
Subjects:
fetal tracheal occlusion
congenital diaphragm hernia
lung development
basal cell
Yap (Hippo) signaling
mechanotransduction
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.780166/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2021.780166/full

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