Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier

In states of intestinal dysbiosis, a perturbation of the normal microbiome composition, the intestinal epithelial barrier (IEB) permeability is increased as a result of the disruption of the epithelial tight junction protein network, in which occludin is mostly affected. The loss of IEB integrity pr...

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Bibliographic Details
Main Authors: Lea Tunisi, Nicola Forte, Alba Clara Fernández-Rilo, Isabella Mavaro, Raffaele Capasso, Livia D'Angelo, Nataša Milić, Luigia Cristino, Vincenzo Di Marzo, Letizia Palomba
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Endocrinology
Subjects:
gut-brain axis
gut microbiota
orexins
lipopolysaccharides
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00219/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00219/full

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