MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

Apoptosis and calcification of endplate chondrocytes (EPCs) can exacerbate intervertebral disc degeneration (IVDD). Mesenchymal stem cell-derived exosomes (MSC-exosomes) are reported to have the therapeutic potential in IVDD. However, the effects and related mechanisms of MSC-exosomes on EPCs are st...

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Bibliographic Details
Main Authors: Lin Xie, Zhenhao Chen, Ming Liu, Weibo Huang, Fei Zou, Xiaosheng Ma, Jie Tao, Jingkang Guo, Xinlei Xia, Feizhou Lyu, Hongli Wang, Chaojun Zheng, Jianyuan Jiang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Mesenchymal stem cells
endplate chondrocytes
exosomes
intervertebral disc degeneration
miR-31-5p
ATF6
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302973

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http://www.sciencedirect.com/science/article/pii/S2162253120302973

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