Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

S100A8/A9 is an endogenous alarmin secreted by myeloid cells during many acute and chronic inflammatory disorders. Despite increasing evidence of the proinflammatory effects of extracellular S100A8/A9, little is known about its intracellular function. Here, we show that cytosolic S100A8/A9 is indisp...

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Bibliographic Details
Main Authors: Matteo Napoli, Roland Immler, Ina Rohwedder, Valerio Lupperger, Johannes Pfabe, Mariano Gonzalez Pisfil, Anna Yevtushenko, Thomas Vogl, Johannes Roth, Melanie Salvermoser, Steffen Dietzel, Marjan Slak Rupnik, Carsten Marr, Barbara Walzog, Markus Sperandio, Monika Pruenster
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
neutrophil recruitment
intracellular S100A8/A9
calcium signaling
LFA-1 integrin clustering
acute inflammation
intracellular signaling
Online Access:https://elifesciences.org/articles/96810

Internet

https://elifesciences.org/articles/96810

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