A novel gene functional similarity calculation model by utilizing the specificity of terms and relationships in gene ontology

Abstract Background Recently, with the foundation and development of gene ontology (GO) resources, numerous works have been proposed to compute functional similarity of genes and achieved series of successes in some research fields. Focusing on the calculation of the information content (IC) of term...

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Bibliographic Details
Main Authors: Zhen Tian, Haichuan Fang, Yangdong Ye, Zhenfeng Zhu
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-022-04557-6