Prevalence of the serpin peptidase inhibitor (alpha-1-antitrypsin) PI*S and PI*Z alleles in Brazilian children with liver disease

Prevalence of the serpin peptidase inhibitor (alpha-1-antitrypsin) PI*S and PI*Z alleles in Brazilian children with liver disease

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1) deficiency is one of the main genetic causes related to liver disease in children. In SERPINA1 deficiency the most frequent SERPINA1 alleles found are the PI*S and PI*Z alleles. We used the polymerase chai...

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Bibliographic Details
Main Authors: Guilherme Baldo, Ana Ayala, Matias Melendez, Karina Nonnemacher, Luciane Lima, Sandra Leistner Segal, Carlos Kieling, Sandra Gonçalves Vieira, Cristina Targa Ferreira, Themis Reverbel da Silveira, Roberto Giugliani, Ursula Matte
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2008-01-01
Series:Genetics and Molecular Biology
Subjects:
alpha-1-antitrypsin deficiency
liver disease
pediatric patients
SERPINA1
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000300005

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