The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy

Hematological malignancy develops and applies various mechanisms to induce immune escape, in part through an immunosuppressive microenvironment. Adenosine is an immunosuppressive metabolite produced at high levels within the tumor microenvironment (TME). Adenosine signaling through the A2A receptor...

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Bibliographic Details
Main Authors: Xuan Jiang, Xiaofang Wu, Yuxi Xiao, Penglin Wang, Jiamian Zheng, Xiuli Wu, Zhenyi Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
CD39
CD73
T cells
hematological malignancy
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1110325/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1110325/full

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