Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Abstract Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known to protect tumour cells from ferroptosis upon cysteine starvation through transamination. However, whether amino acids‐produced meta...

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Bibliographic Details
Main Authors: Dong Liu, Chun‐hui Liang, Bin Huang, Xiao Zhuang, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin, Renjie Chai, Bo Chu
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Advanced Science
Subjects:
3‐HA
5‐HT
ferroptosis
3‐hydroxyanthranilate 3,4‐dioxygenase (HAAO)
kynureninase (KYNU
monoamine oxidase A (MAOA) 
Online Access:https://doi.org/10.1002/advs.202204006

Internet

https://doi.org/10.1002/advs.202204006

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