Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation InjurySummary

Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation InjurySummary

Background & Aims: Intestinal crypts have a remarkable capacity to regenerate after injury from loss of crypt base columnar (CBC) stem cells. After injury, facultative stem cells (FSCs) are activated to replenish the epithelium and replace lost CBCs. Our aim was to assess the role of insulin...

Full description

Bibliographic Details
Main Authors: Natacha Bohin, Kevin P. McGowan, Theresa M. Keeley, Elizabeth A. Carlson, Kelley S. Yan, Linda C. Samuelson
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
IGF-1
Raptor
Rapamycin
Intestinal Repair
Crypt Regeneration
Intestinal Stem Cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20300898

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X20300898

Similar Items