Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9
The RNA-guided DNA endonuclease Cas9 from Corynebacterium diphtheriae (CdCas9) recognizes a promiscuous protospacer adjacent motif (PAM). Here the authors provide insights into the CdCas9-mediated PAM recognition mechanism by determining the 2.9 Å crystal structure of CdCas9 in complex with the guid...
| Autori principali: | , , , , , , , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
Nature Portfolio
2019-04-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-019-09741-6 |