Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats

Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats

PURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) pr...

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Bibliographic Details
Main Authors: Camila Ferreira Leite, Fábio André Marangoni, Enilton Aparecido Camargo, Angélica de Fátima de Assunção Braga, Ivan Felizardo Contrera Toro, Edson Antunes, Elen Cristina Tiezem Landucci, Ricardo Kalaf Mussi
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2013-04-01
Series:Acta Cirúrgica Brasileira
Subjects:
Models, Animal
Pulmonary Ventilation
Simvastatin
Thoracic Surgery
Inflammation
Rats
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000400003&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013000400003&tlng=en

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