Disease modeling of ADAMTS9-related nephropathy using kidney organoids reveals its roles in tubular cells and podocytes

Disease modeling of ADAMTS9-related nephropathy using kidney organoids reveals its roles in tubular cells and podocytes

IntroductionMutations in ADAMTS9 cause nephronophthisis-related ciliopathies (NPHP-RC), which are characterized by multiple developmental defects and kidney diseases. Patients with NPHP-RC usually have normal glomeruli and negligible or no proteinuria. Herein, we identified novel compound-heterozygo...

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Bibliographic Details
Main Authors: Seyoung Yu, Yo Jun Choi, John Hoon Rim, Hye-Youn Kim, Nasim Bekheirnia, Sarah Jane Swartz, Hongzheng Dai, Shen Linda Gu, Soyeon Lee, Ryuichi Nishinakamura, Friedhelm Hildebrandt, Mir Reza Bekheirnia, Heon Yung Gee
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Medicine
Subjects:
Nephronophthisis-related ciliopathy
ADAMTS9
kidney organoid
single-cell RNA sequencing
podocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1089159/full

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https://www.frontiersin.org/articles/10.3389/fmed.2023.1089159/full

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