Effects of GC bias in next-generation-sequencing data on de novo genome assembly.

Effects of GC bias in next-generation-sequencing data on de novo genome assembly.

Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger sequencing. However, NGS poses new computational challenges to de novo genome assembly. Among the challenges, GC bias in NG...

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Bibliographic Details
Main Authors: Yen-Chun Chen, Tsunglin Liu, Chun-Hui Yu, Tzen-Yuh Chiang, Chi-Chuan Hwang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3639258?pdf=render

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http://europepmc.org/articles/PMC3639258?pdf=render

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