Malignant DFFB isoform switching promotes leukemia survival in relapse pediatric T‐cell acute lymphoblastic leukemia

Malignant DFFB isoform switching promotes leukemia survival in relapse pediatric T‐cell acute lymphoblastic leukemia

Abstract With modern treatment most children with acute lymphoblastic leukemia (ALL) survive without relapse. However, for children who relapse the prognosis is still poor, especially in children with T‐cell phenotype (T‐ALL) and remains the major cause of death. The exact mechanism of relapse is cu...

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Bibliographic Details
Main Authors: Sabina Enlund, Indranil Sinha, Amanda Ramilo Amor, Shahrzad Shirazi Fard, Ekaterina Pokrovskaja Tamm, Qingfei Jiang, Vanessa Lundin, Anna Nilsson, Frida Holm
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:eJHaem
Subjects:
acute leukaemia
alternative mRNA splicing
apoptosis
CD34
childhood leukaemia
relapse
Online Access:https://doi.org/10.1002/jha2.634

Internet

https://doi.org/10.1002/jha2.634

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