Antiproliferative and genotoxic potential of xanthen-3-one derivatives

Antiproliferative and genotoxic potential of xanthen-3-one derivatives

Twelve previously synthesized, biologically active 2,6,7-trihydroxyxanthen-3-one derivatives were evaluated in vitro for antiproliferative activity. Compounds were screened against HeLa, SW620, HepG2 and A549 tumor cell lines. Compound with the trifluormethyl group on C-4’ position of the phenyl rin...

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Bibliographic Details
Main Authors: Veljović Elma, Špirtović-Halilović Selma, Muratović Samija, Osmanović Amar, Haverić Sanin, Haverić Anja, Hadžić Maida, Salihović Mirsada, Malenica Maja, Šapčanin Aida, Završnik Davorka
Format: Article
Language:English
Published: Sciendo 2019-12-01
Series:Acta Pharmaceutica
Subjects:
antiproliferative activity
genotoxic potential
docking study
xanthen-3-one derivatives
cytokinesis-block micronucleus cytome assay
Online Access:https://doi.org/10.2478/acph-2019-0044

Internet

https://doi.org/10.2478/acph-2019-0044

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