An Ovarian Steroid Metabolomic Pathway Analysis in Basal and Polycystic Ovary Syndrome (PCOS)-like Gonadotropin Conditions Reveals a Hyperandrogenic Phenotype Measured by Mass Spectrometry

An Ovarian Steroid Metabolomic Pathway Analysis in Basal and Polycystic Ovary Syndrome (PCOS)-like Gonadotropin Conditions Reveals a Hyperandrogenic Phenotype Measured by Mass Spectrometry

Prior work has demonstrated that murine ovarian explants and isolated ovarian follicles can recapitulate human-like 28-day cycles in vitro with normal patterns of estradiol and progesterone secretion in response to gonadotropin stimulation. The objective of this study was to manipulate the gonadotro...

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Bibliographic Details
Main Authors: Emma S. Gargus, Yeunook Bae, Jiexi Chen, Kristine J. Moss, Asia N. Ingram, Jiyang Zhang, Nathan T. Montgomery, Christina E. Boots, William E. Funk, Teresa K. Woodruff
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
polycystic ovary syndrome
ovarian steroidogenesis
mass spectrometry
in vitro ovarian culture
luteinizing hormone
Online Access:https://www.mdpi.com/2227-9059/10/7/1646

Internet

https://www.mdpi.com/2227-9059/10/7/1646

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