Targeting evolution of antibiotic resistance by SOS response inhibition

Targeting evolution of antibiotic resistance by SOS response inhibition

Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homol...

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Bibliographic Details
Main Authors: Alexander Yakimov, Irina Bakhlanova, Dmitry Baitin
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Bacterial SOS response
RecA inhibition
Antibiotic resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021000076

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http://www.sciencedirect.com/science/article/pii/S2001037021000076

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