Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: Outcomes for genetic screening techniques

Evolution of cyclizing 5-aminolevulinate synthases in the biosynthesis of actinomycete secondary metabolites: Outcomes for genetic screening techniques

A combined approach, comprising PCR screening and genome mining, was used to unravel the diversity and phylogeny of genes encoding 5-aminolevulinic acid synthases (ALASs, hemA gene products) in streptomycetes-related strains. In actinomycetes, these genes were believed to be directly connected with...

Full description

Bibliographic Details
Main Authors: Katerina ePetrickova, Alica eChronakova, Tomas eZelenka, Tomas eChrudimsky, Stanislav ePospisil, Miroslav ePetricek, Vaclav eKristufek
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Microbiology
Subjects:
Streptomyces
genetic screening
horizontal gene transfer
secondary metabolites
gene evolution
5-Aminolevulinate synthase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00814/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00814/full

Similar Items