Converging evidence for epistasis between ANK3 and potassium channel gene KCNQ2 in bipolar disorder

Converging evidence for epistasis between ANK3 and potassium channel gene KCNQ2 in bipolar disorder

Genome-wide association studies (GWAS) have implicated ANK3 as a susceptibility gene for bipolar disorder (BP). We examined whether epistasis with ANK3 may contribute to the missing heritability in BP. We first identified via the STRING database 14 genes encoding proteins with prior biological evide...

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Bibliographic Details
Main Authors: Jennifer Toolan Judy, Fayaz eSeifuddin, Mehdi ePirooznia, Pamela Belmonte Mahon, Fernando S. Goes, Dubravka eJancic, Thomas eSchultze, Sven eCichon, Markus M Nöthen, Marcella eRietschel, Bipolar Genome Study e(BiGS) Consortium, J. Raymond eDePaulo, James B. Potash, Peter P. Zandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Genetics
Subjects:
Bipolar Disorder
Interaction
ion channel
Epistasis
ANK3
KCNQ2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00087/full

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