Biodistribution and function of coupled polymer-DNA origami nanostructures

Abstract Spatial control over the distribution of therapeutics is a highly desired feature, which could limit the side effects of many drugs. Here we describe a nanoscale agent, fabricated from a coupled polymer-DNA origami hybrid that exhibits stability in serum and slow diffusion through tissues,...

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Bibliographic Details
Main Authors: Noah Joseph, Anastasia Shapiro, Ella Gillis, Shirin Barkey, Almogit Abu-Horowitz, Ido Bachelet, Boaz Mizrahi
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-46351-1