Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery

Abstract Background There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epithelial-mesenchymal transition (EMT), and immune microenvironment contribute to the progression of CRLM. A main glycolytic enzyme pyruvate Kinase...

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Bibliographic Details
Main Authors: Li Long, Wei Xiong, Fenwang Lin, Jiazhen Hou, Guihua Chen, Taoxing Peng, Yihao He, Rui Wang, Qin Xu, Yongzhuo Huang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Shikonin
Colorectal cancer liver metastasis
Glycolysis
Pyruvate kinase M2 (PKM2)
Epithelial-mesenchymal transition (EMT)
Immune microenvironment
Online Access:https://doi.org/10.1186/s13046-023-02688-z

Internet

https://doi.org/10.1186/s13046-023-02688-z

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