Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors

Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors

Blocking protein-protein interactions (PPI) using small molecules or peptides modulates biochemical pathways and has therapeutic significance. PPI inhibition for designing drug-like molecules is a new area that has been explored extensively during the last decade. Considering the number of available...

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Bibliographic Details
Main Authors: Rushikesh Sable, Seetharama Jois
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
protein-protein interactions
docking
protein docking
hot spots
virtual screening
drug-like molecules
Online Access:http://www.mdpi.com/1420-3049/20/6/11569

Internet

http://www.mdpi.com/1420-3049/20/6/11569

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