In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P<sub>1</sub>) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P<sub>1</sub> Receptor Modulator

In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P<sub>1</sub>) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P<sub>1</sub> Receptor Modulator

Cenerimod is a potent, selective sphingosine 1-phosphate receptor 1 (S1P<sub>1</sub>) modulator currently investigated in a Phase IIb study in patients with systemic lupus erythematosus (SLE) (NCT03742037). S1P<sub>1</sub> receptor modulators sequester circulating lymphocytes...

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Bibliographic Details
Main Authors: Lisa Schlicher, Paulina Kulig, Audrey von Münchow, Mark J. Murphy, Marcel P. Keller
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
S1P<sub>1</sub> receptor modulator
lymphocyte
chemotaxis
glucocorticoids
systemic lupus erythematosus (SLE)
Online Access:https://www.mdpi.com/1422-0067/23/3/1191

Internet

https://www.mdpi.com/1422-0067/23/3/1191

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