Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration

Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration

Summary: Investigating mechanisms that regulate endothelial cell (EC) growth and survival is important for understanding EC homeostasis and how ECs maintain stem cell niches. We report here that targeted loss of Id genes in adult ECs results in dilated, leaky sinusoids and a pro-inflammatory state t...

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Bibliographic Details
Main Authors: Stephen Gadomski, Satyendra K. Singh, Shweta Singh, Tanmoy Sarkar, Kimberly D. Klarmann, Maximillian Berenschot, Steven Seaman, Brad Jakubison, Kristbjorn O. Gudmundsson, Stephen Lockett, Jonathan R. Keller
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305210

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http://www.sciencedirect.com/science/article/pii/S2211124720305210

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