In Silico and In Vitro Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker

In Silico and In Vitro Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker

The α-synucleinopathies are a group of neurodegenerative diseases characterized by the deposition of α-synuclein aggregates (α-syn) in the brain. Currently, there is no suitable tracer to enable a definitive early diagnosis of these diseases. We reported candidates based on 4,4′-disarylbisthiazole (...

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Bibliographic Details
Main Authors: Bright C. Uzuegbunam, Junhao Li, Wojciech Paslawski, Wolfgang Weber, Per Svenningsson, Hans Ågren, Behrooz Hooshyar Yousefi
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein aggregates
4,4′-diarylbisthiazole
binding affinity
Hantzsch thiazole synthesis
lipophilicity
O-fluoroethylation
Online Access:https://www.mdpi.com/1422-0067/24/22/16445

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https://www.mdpi.com/1422-0067/24/22/16445

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