Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

<p>Abstract</p> <p>Background</p> <p>Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis. Clearance of degenerated myelin by phagocytosis is essenti...

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Bibliographic Details
Main Authors: Hadas Smadar, Spira Maya, Hanisch Uwe-Karsten, Reichert Fanny, Rotshenker Shlomo
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Macrophage
Phagocytosis
Myelin
Complement receptor-3
Syk
Cofilin
Online Access:http://www.jneuroinflammation.com/content/9/1/166

Internet

http://www.jneuroinflammation.com/content/9/1/166

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