Characterization and biological evaluation of some novel pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones synthesized via the Gewald reaction

Characterization and biological evaluation of some novel pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones synthesized via the Gewald reaction

The synthesis of substituted pyrazolo[3’,4’:4,5]thieno[2,3-d]pyrimidin-8-ones (IIIa–j) from 5-amino-3-methyl-1H-thieno[3,2-c]pyrazole-6-carbonitrile (II) is described. The key compound II was synthesized from (5-methyl--2,4-dihydro-3H-pyrazol-3-ylidene)malononitrile I via the Gewald reaction. The sy...

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Bibliographic Details
Main Authors: VIRESH H. SHAH, SHAILESH J. VAGHASIA, SAMIR H. JARSANIA, AMIT R. TRIVEDI, DIPTI K. DODIYA
Format: Article
Language:English
Published: Serbian Chemical Society 2008-07-01
Series:Journal of the Serbian Chemical Society
Subjects:
pyrazolo[3’
4’:4
5]thieno[2
3-d]pyrimidin-8-ones
carbonitrile
Gewald reaction
antimicrobial activity
Online Access:http://www.shd.org.rs/JSCS/Vol73/No7/JSCS-3751.pdf

Internet

http://www.shd.org.rs/JSCS/Vol73/No7/JSCS-3751.pdf

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