Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations
Background CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-05-01
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| Series: | Annals of Human Biology |
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| Online Access: | http://dx.doi.org/10.1080/03014460.2022.2100477 |
| _version_ | 1797685168650059776 |
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| author | Grazyna Adler Izabela Uzar Amina Valjevac Emina Kiseljakovic Emir Mahmutbegovic Nermin N. Salkic Mateusz A. Adler Nevena Mahmutbegovic |
| author_facet | Grazyna Adler Izabela Uzar Amina Valjevac Emina Kiseljakovic Emir Mahmutbegovic Nermin N. Salkic Mateusz A. Adler Nevena Mahmutbegovic |
| author_sort | Grazyna Adler |
| collection | DOAJ |
| description | Background CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3, *4, *6 and *7, and C and T of ABCB1 in Poles, Belarusians and Bosnians and to compare it with the data reported from other European populations. Subjects and methods Overall, 511 unrelated healthy subjects from Poland (n = 239), Belarus (n = 104) and Bosnia and Herzegovina (n = 168) were included in this study. Allele frequencies and statistical parameters (AMOVA version 2.9.3) were determined. Results In Poles, Belarusians and Bosnians the *3 allele of CYP3A5 was the most common, and wild-type allele *1, were: 5.8%, 1.6% and 2.1%, respectively. Allele *2 was very rare, and alleles *4, *6 and *7 were not detected. For the populations mentioned above, the ABCB1 allele C was: 48.1%, 51.4%, 52.4%, respectively. Conclusion In compared populations, the distribution of CYP3A5 variants but not ABCB1, differed significantly. Alleles *4, *6 and *7 of CYP3A5 did not occur or occurred rarely. |
| first_indexed | 2024-03-12T00:40:14Z |
| format | Article |
| id | doaj.art-5e06c2c236cc4e47895c4453cb573cf0 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:40:14Z |
| publishDate | 2022-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-5e06c2c236cc4e47895c4453cb573cf02023-09-15T08:45:20ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332022-05-01493-421021510.1080/03014460.2022.21004772100477Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populationsGrazyna Adler0Izabela Uzar1Amina Valjevac2Emina Kiseljakovic3Emir Mahmutbegovic4Nermin N. Salkic5Mateusz A. Adler6Nevena Mahmutbegovic7Department of Studies in Antropogenetics and Biogerontology, Pomeranian Medical UniversityDepartment of General Pharmacology and Pharmacoeconomics, Pomeranian Medical UniversityDepartment of Human Physiology, Faculty of Medicine, University of SarajevoDepartment of Medical Biochemistry, Faculty of Medicine, University of SarajevoInstitution of Health Protection of Women and Motherhood Canton SarajevoDepartment of Gastroenterology and Hepatology, University Clinical Centre TuzlaCredit Suisse, sp. z o.oNeurology Clinic, Clinical Center of University of SarajevoBackground CYP3A5 enzyme encoded by CYP3A5 is important for drug metabolism in gut and liver, whereas P-glycoprotein by ABCB1, is an ATP-dependent drug efflux pump which exports endo- and exogenous substances outside the cell. Aim The study was to assess the prevalence of CYP3A5 alleles: *1, *2, *3, *4, *6 and *7, and C and T of ABCB1 in Poles, Belarusians and Bosnians and to compare it with the data reported from other European populations. Subjects and methods Overall, 511 unrelated healthy subjects from Poland (n = 239), Belarus (n = 104) and Bosnia and Herzegovina (n = 168) were included in this study. Allele frequencies and statistical parameters (AMOVA version 2.9.3) were determined. Results In Poles, Belarusians and Bosnians the *3 allele of CYP3A5 was the most common, and wild-type allele *1, were: 5.8%, 1.6% and 2.1%, respectively. Allele *2 was very rare, and alleles *4, *6 and *7 were not detected. For the populations mentioned above, the ABCB1 allele C was: 48.1%, 51.4%, 52.4%, respectively. Conclusion In compared populations, the distribution of CYP3A5 variants but not ABCB1, differed significantly. Alleles *4, *6 and *7 of CYP3A5 did not occur or occurred rarely.http://dx.doi.org/10.1080/03014460.2022.2100477snpscytochrome p450 3a5atp-binding cassette b1pharmacogenetics |
| spellingShingle | Grazyna Adler Izabela Uzar Amina Valjevac Emina Kiseljakovic Emir Mahmutbegovic Nermin N. Salkic Mateusz A. Adler Nevena Mahmutbegovic Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations Annals of Human Biology snps cytochrome p450 3a5 atp-binding cassette b1 pharmacogenetics |
| title | Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations |
| title_full | Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations |
| title_fullStr | Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations |
| title_full_unstemmed | Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations |
| title_short | Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations |
| title_sort | genetic diversity of cyp3a5 and abcb1 variants in east central and south european populations |
| topic | snps cytochrome p450 3a5 atp-binding cassette b1 pharmacogenetics |
| url | http://dx.doi.org/10.1080/03014460.2022.2100477 |
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