The substitution at residue 218 of the NS5 protein methyltransferase domain of Tembusu virus impairs viral replication and translation and may triggers RIG-I-like receptor signaling

The substitution at residue 218 of the NS5 protein methyltransferase domain of Tembusu virus impairs viral replication and translation and may triggers RIG-I-like receptor signaling

ABSTRACT: Flavivirus RNA cap-methylation plays an important role in viral infection, proliferation, and escape from innate immunity. The methyltransferase (MTase) of the flavivirus NS5 protein catalyzes viral RNA methylation. The E218 amino acid of the NS5 protein MTase domain is one of the active s...

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Bibliographic Details
Main Authors: Xuedong Wu, Yuhong Pan, Juan Huang, Shanzhi Huang, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Ying Wu, Qiao Yang, Shaqiu Zhang, Xumin Ou, Ling Zhang, Yunya Liu, Yanling Yu, Qun Gao, Sai Mao, Di Sun, Bin Tian, Zhongqiong Yin, Bo Jing, Anchun Cheng, Renyong Jia
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Poultry Science
Subjects:
TMUV
MTase domain
replication
translation
RIG-I-like receptor signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S003257912200308X

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http://www.sciencedirect.com/science/article/pii/S003257912200308X

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