Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here, we show that Rpl24Bst...

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Bibliographic Details
Main Authors: John RP Knight, Nikola Vlahov, David M Gay, Rachel A Ridgway, William James Faller, Christopher Proud, Giovanna R Mallucci, Tobias von der Haar, Christopher Mark Smales, Anne E Willis, Owen J Sansom
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
translation
protein sythesis
intestinal cancer
in vivo models
RPL24
eEF2K
Online Access:https://elifesciences.org/articles/69729

Internet

https://elifesciences.org/articles/69729

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