Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN Status

Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN Status

Radioresistance compromises the efficacy of radiotherapy for glioblastoma multiforme (GBM), the most devastating and common brain tumor. The present study investigated the relationship between radiation tolerance and formation of polyploid/multinucleated giant (PGCC/MGCC) and quiescent/senescent slo...

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Bibliographic Details
Main Authors: Lina Alhaddad, Roman Chuprov-Netochin, Margarita Pustovalova, Andreyan N. Osipov, Sergey Leonov
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma multiforme
radioresistance
senescence
multinucleated giant cancer cell (MGCC)
polyploid giant cancer cell (PGCC)
p53
Online Access:https://www.mdpi.com/1422-0067/24/2/1228

Internet

https://www.mdpi.com/1422-0067/24/2/1228

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