Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury

Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury

If idiosyncratic drug-induced liver injury (IDILI) is immune-mediated, it is possible that an individual’s prior exposure to antigens may affect their susceptibility to IDILI. An individual’s repertoire of memory immune cells is shaped by every past exposure to antigens. Subsequent drug-induced adve...

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Bibliographic Details
Main Authors: Alastair Mak, Alexander Johnston, Jack Uetrecht
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Immunotoxicology
Subjects:
Idiosyncratic drug-induced liver injury
amodiaquine
immunization
immune tolerance
animal model
Online Access:http://dx.doi.org/10.1080/1547691X.2017.1290716

Internet

http://dx.doi.org/10.1080/1547691X.2017.1290716

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