Celastrol inhibits LL37-induced rosacea by inhibiting Ca2+/CaMKII-mTOR-NF-κB activation

Celastrol inhibits LL37-induced rosacea by inhibiting Ca2+/CaMKII-mTOR-NF-κB activation

Rosacea is a common chronic facial inflammatory disease that affects millions of people worldwide. Due to the unclear etiology of rosacea, effective treatments are limited. Celastrol, a plant-derived triterpene, has been reported to alleviate inflammation in various diseases. However, whether celast...

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Bibliographic Details
Main Authors: Qingyu Zeng, Jin Yang, Guorong Yan, Linglin Zhang, Peiru Wang, Haiyan Zhang, Qi Chen, Yajing Cao, Xiaojing Liu, Xiuli Wang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Rosacea
Celastrol
Ca2+
mTOR
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222006813

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http://www.sciencedirect.com/science/article/pii/S0753332222006813

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