Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia

Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia

The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice. This model has been used to study the neurological disorder of trigeminovascular pain or migraine, a debilitating form of hyperalgesia. The present study validates hyperalgesia in an established mouse model of...

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Bibliographic Details
Main Authors: Hyeonsoo Jeong, Laura S. Moye, Bruce R. Southey, Alvaro G. Hernandez, Isaac Dripps, Elena V. Romanova, Stanislav S. Rubakhin, Jonathan V. Sweedler, Amynah A. Pradhan, Sandra L. Rodriguez-Zas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Systems Neuroscience
Subjects:
hyperalgesia
migraine
RNA-seq
transcription factor
immune response
synapse processes
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2018.00063/full

Internet

https://www.frontiersin.org/article/10.3389/fnsys.2018.00063/full

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