Targeted Gene Editing in Porcine Spermatogonia

Targeted Gene Editing in Porcine Spermatogonia

To study the pathophysiology of human diseases, develop innovative treatments, and refine approaches for regenerative medicine require appropriate preclinical models. Pigs share physiologic and anatomic characteristics with humans and are genetically more similar to humans than are mice. Genetically...

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Bibliographic Details
Main Authors: Dennis Webster, Alla Bondareva, Staci Solin, Taylor Goldsmith, Lin Su, Nathalia de Lima e Martins Lara, Daniel F. Carlson, Ina Dobrinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
pig
spermatogonia
gene targeting
CRISPR/Cas9
homology directed repair
homology-mediated end joining
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.627673/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.627673/full

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