Breast cancer associated CD169+ macrophages possess broad immunosuppressive functions but enhance antibody secretion by activated B cells

Breast cancer associated CD169+ macrophages possess broad immunosuppressive functions but enhance antibody secretion by activated B cells

CD169+ resident macrophages in lymph nodes of breast cancer patients are for unknown reasons associated with a beneficial prognosis. This contrasts CD169+ macrophages present in primary breast tumors (CD169+ TAMs), that correlate with a worse prognosis. We recently showed that these CD169+ TAMs were...

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Bibliographic Details
Main Authors: Frida Björk Gunnarsdottir, Oscar Briem, Aida Yifter Lindgren, Eva Källberg, Cajsa Andersen, Robert Grenthe, Cassandra Rosenqvist, Camilla Rydberg Millrud, Mika Wallgren, Hannah Viklund, Daniel Bexell, Martin E. Johansson, Ingrid Hedenfalk, Catharina Hagerling, Karin Leandersson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
breast cancer
macrophage
CD169
tolerance
type I IFN
B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180209/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180209/full

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