Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and plays a key role in attaching the cytokinetic ring (CR) to the plasma membrane (PM). Cdc15’s abilities to bind to the membrane and oligomerize via its F-BAR domain are inhibited by phosphorylation of its intrinsica...

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Bibliographic Details
Main Authors: Rahul Bhattacharjee, Aaron R Hall, MariaSanta C Mangione, Maya G Igarashi, Rachel H Roberts-Galbraith, Jun-Song Chen, Dimitrios Vavylonis, Kathleen L Gould
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
cytokinesis
F-BAR protein
fission yeast
intrinsically disordered region
phase separation
Online Access:https://elifesciences.org/articles/83062

Internet

https://elifesciences.org/articles/83062

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