Studies on condensation of 1,3-dicarbonyls with malononitrile: Synthesis of 2-pyridinones
A simple and novel method to the chemoselective synthesis of 3-cyano-2-pyridinone derivatives from a Knoevenagel condensation of malononitrile with the carbonyl group of 1,3-dicarbonyls followed by cycloaddition and isomerization, is reported. The reactions occur in ethanol and water at reflux, in t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-05-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535213003067 |