Studies on condensation of 1,3-dicarbonyls with malononitrile: Synthesis of 2-pyridinones

Studies on condensation of 1,3-dicarbonyls with malononitrile: Synthesis of 2-pyridinones

A simple and novel method to the chemoselective synthesis of 3-cyano-2-pyridinone derivatives from a Knoevenagel condensation of malononitrile with the carbonyl group of 1,3-dicarbonyls followed by cycloaddition and isomerization, is reported. The reactions occur in ethanol and water at reflux, in t...

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Bibliographic Details
Main Authors:	Mohammad Seifi, Hassan Sheibani
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Arabian Journal of Chemistry
Subjects:	1,3-Dicarbonyls Malononitrile 2-Pyridinones Knoevenagel condensation Cycloaddition and isomerization
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535213003067

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