Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

Abstract Background The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cancers is the subject of investigation. This study was aimed at assessing t...

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Bibliographic Details
Main Authors: Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Askar Abubakar, Stephanie H. Lim, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin, Cheok Soon Lee
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Cancer
Subjects:
DNA damage response
MRE11-RAD50-NBS1 complex
Rectal cancer
Prognosis
Biomarkers
Neoadjuvant radiotherapy
Online Access:http://link.springer.com/article/10.1186/s12885-018-4776-9

Internet

http://link.springer.com/article/10.1186/s12885-018-4776-9

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