Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies

Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies

The interactions of small molecule drugs with plasma serum albumin are important because of the influence of such interactions on the pharmacokinetics of these therapeutic agents. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) is one such drug candidate that has recently gained attention for...

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Bibliographic Details
Main Authors: Shokoufeh Hashempour, Nahid Shahabadi, Aishat Adewoye, Brennen Murphy, Camaray Rouse, Brian A. Salvatore, Christopher Stratton, Elahe Mahdavian
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
AICAR
human serum albumin (HSA)
static fluorescence quenching
synchronous fluorescence
3D fluorescence
FRET
Online Access:https://www.mdpi.com/1420-3049/25/22/5410

Internet

https://www.mdpi.com/1420-3049/25/22/5410

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