Somatic variants of potential clinical significance in the tumors of BRCA phenocopies

Somatic variants of potential clinical significance in the tumors of BRCA phenocopies

Abstract Background BRCA phenocopies are individuals with the same phenotype (i.e. cancer consistent with Hereditary Breast and Ovarian Cancer syndrome = HBOC) as their affected relatives, but not the same genotype as assessed by blood germline testing (i.e. they do not carry a germline BRCA1 or BRC...

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Bibliographic Details
Main Authors: Lela Buckingham, Rachel Mitchell, Mark Maienschein-Cline, Stefan Green, Vincent Hong Hu, Melody Cobleigh, Jacob Rotmensch, Kelly Burgess, Lydia Usha
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
Phenocopy
HBOC
NGS
Somatic mutations
Online Access:http://link.springer.com/article/10.1186/s13053-019-0117-5

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http://link.springer.com/article/10.1186/s13053-019-0117-5

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