Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization

Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization

Abstract Adducin (Add) is an actin binding protein participating in the stabilization of actin/spectrin networks, epithelial junctional turnover and cardiovascular disorders such as hypertension. Recently, we demonstrated that Add is required for adherens junctions (AJ) integrity. Here we hypothesiz...

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Bibliographic Details
Main Authors: Sina Moztarzadeh, Mariya Y. Radeva, Sara Sepic, Katharina Schuster, Ibrahim Hamad, Jens Waschke, Alexander García-Ponce
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18964-5

Internet

https://doi.org/10.1038/s41598-022-18964-5

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