A Potential Quorum-Sensing Inhibitor for Bronchiectasis Therapy: Quercetin–Chitosan Nanoparticle Complex Exhibiting Superior Inhibition of Biofilm Formation and Swimming Motility of <i>Pseudomonas aeruginosa</i> to the Native Quercetin

A Potential Quorum-Sensing Inhibitor for Bronchiectasis Therapy: Quercetin–Chitosan Nanoparticle Complex Exhibiting Superior Inhibition of Biofilm Formation and Swimming Motility of <i>Pseudomonas aeruginosa</i> to the Native Quercetin

Quercetin (QUE)—a plant-derived flavonoid, is recently established as an effective quorum sensing (QS) inhibiting agent in <i>Pseudomonas aeruginosa</i>—the main bacterial pathogen in bronchiectasis lungs. Successful clinical application of QUE, however, is hindered by its low solubility...

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Bibliographic Details
Main Authors: The-Thien Tran, Kunn Hadinoto
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
quercetin nanoparticles
drug-polyelectrolyte complexation
amorphous drugs
quorum sensing
bronchiectasis therapy
<i>Pseudomonas</i> biofilm
Online Access:https://www.mdpi.com/1422-0067/22/4/1541

Internet

https://www.mdpi.com/1422-0067/22/4/1541

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