SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system

SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system

BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for COVID-19, has caused nearly 7 million deaths worldwide. Severe cases are marked by an aggressive inflammatory response known as hypercytokinemia, contributing to endothelial damage. Although vaccination has reduc...

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Bibliographic Details
Main Authors: Christopher J. Hatch, Sebastian D. Piombo, Jennifer S. Fang, Johannes S. Gach, Makena L. Ewald, William K. Van Trigt, Brian G. Coon, Jay M. Tong, Donald N. Forthal, Christopher C. W. Hughes
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
COVID-19
endothelial dysfunction
hypercytokinemia
microphysiological systems
shear stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2024.1360364/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2024.1360364/full

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