Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing

Abstract Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5 (Cdk5) as...

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Bibliographic Details
Main Authors: Mubashir Ahmad, Benjamin Thilo Krüger, Torsten Kroll, Sabine Vettorazzi, Ann-Kristin Dorn, Florian Mengele, Sooyeon Lee, Sayantan Nandi, Dilay Yilmaz, Miriam Stolz, Naveen Kumar Tangudu, David Carro Vázquez, Johanna Pachmayr, Ion Cristian Cirstea, Maja Vujic Spasic, Aspasia Ploubidou, Anita Ignatius, Jan Tuckermann
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00195-z

Internet

https://doi.org/10.1038/s41413-022-00195-z

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