Optimization of trans-4-hydroxyproline synthesis pathway by rearrangement center carbon metabolism in Escherichia coli

Optimization of trans-4-hydroxyproline synthesis pathway by rearrangement center carbon metabolism in Escherichia coli

Abstract Background trans-4-Hydroxyproline (T-4-HYP) is a promising intermediate in the synthesis of antibiotic drugs. However, its industrial production remains challenging due to the low production efficiency of T-4-HYP. This study focused on designing the key nodes of anabolic pathway to enhance...

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Bibliographic Details
Main Authors: Yu Gong, Ruiqi Wang, Ling Ma, Shuo Wang, Changgeng Li, Qingyang Xu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Microbial Cell Factories
Subjects:
Escherichia coli
trans-4-Hydroxyproline
Acetyl-CoA
NADPH supply
NOG pathway
α-Ketoglutarate
Online Access:https://doi.org/10.1186/s12934-023-02236-6

Internet

https://doi.org/10.1186/s12934-023-02236-6

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