A versatile design platform for glycoengineering therapeutic antibodies

A versatile design platform for glycoengineering therapeutic antibodies

Manipulation of glycosylation patterns, i.e., glycoengineering, is incorporated in the therapeutic antibody development workflow to ensure clinical safety, and this approach has also been used to modulate the biological activities, functions, or pharmacological properties of antibody drugs. Whereas...

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Bibliographic Details
Main Authors: Seth D. Ludwig, Zachary J. Bernstein, Christian Agatemor, Kris Dammen-Brower, Jeffrey Ruffolo, Jonah M. Rosas, Jeremy D. Post, Robert N. Cole, Kevin J. Yarema, Jamie B. Spangler
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Protein glycoengineering
immunotherapy
interleukin-2
sialylation
therapeutics
glycosylation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2095704

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2095704

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