Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery

Identifying molecular tags selectively retained on the surface of brain endothelial cells to generate artificial targets for therapy delivery

Abstract Current strategies to identify ligands for brain delivery select candidates based on preferential binding to cell-membrane components (CMC) on brain endothelial cells (EC). However, such strategies generate ligands with inherent brain specificity limitations, as the CMC (e.g., the transferr...

Full description

Bibliographic Details
Main Authors: Giulia Maria Porro, Italo Lorandi, Xueying Liu, Kazunori Kataoka, Giuseppe Battaglia, Daniel Gonzalez-Carter
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Fluids and Barriers of the CNS
Subjects:
Brain targeting
Endocytic rates
Ligand identification
Phage-display
Brain endothelium
Online Access:https://doi.org/10.1186/s12987-023-00493-6

Internet

https://doi.org/10.1186/s12987-023-00493-6

Similar Items